IFNG and osteoarthritis: In conclusion, IFN-γ restriction in the development of Brucella osteoarthritis may be achieved by inducing nitric oxide to curb the release of inflammatory cytokines, inhibit the excessive activation of inflammasomes, and kill some intracellular bacteria (Figure 2) (Campos et al., 2019; Gomes et al., 2021; Lacey et al., 2019).