Knockout C57BL/6 mice with mutations Rag1−/−, IFN-γ−/−, Rag2−/−, Rorc−/−, Tbx21−/−, IFN-γr1−/−, IFN-γr1−/−/Ifnar1−/−, or Tcra−/− were used to study the role of ILCs and IFN-γ in Brucella osteoarthritis and neurological complications. This evidence concerns the gene IFNGR1 and osteoarthritis.