Numerous studies have demonstrated that lncRNA XIST can regulate AML cell proliferation, inhibit cell apoptosis, and consequently influence AML progression. Wang Chong et al. reported that downregulating XIST can decrease MYC expression, thereby reducing drug resistance and promoting apoptosis in AML cells (Wang et al., 2020a; Jiang et al., 2024). The gene discussed is XIST; the disease is acute myeloid leukemia.