The results (Figure 2, HR = 2.46, 95% CI 2.11–2.88, P < 0.001) demonstrated that the aberrant expression of lncRNAs, including high expression of DANCR, SNHG7, HEIH, FOXD3-AS1, MALAT-1, PANDAR, TUG1, ZEB2-AS1, NEAT1, ANRIL, SNHG14, SNHG5, CRNDE, NORAD, RBM5-AS1, and low expression of IRAIN, was significantly associated with reduced OS in AML patients, with a statistically significant difference. The gene discussed is IRAIN; the disease is acute myeloid leukemia.