IRAIN is an antisense long non-coding RNA of IGF1R and is related to the intramolecular loop structure between the DNA promoter and enhancer of IGF1R. (Liang et al., 2020) IRAIN is involved in the interaction with chromatin DNA. Studies have shown that low expression of IRAIN is closely associated with a reduced complete remission rate in AML patients (Pashaiefar et al., 2018; Sun et al., 2014). Here, IGF1R is linked to acute myeloid leukemia.