Currently, extensive research has been conducted on HOTAIR. Numerous studies have demonstrated that lncRNA HOTAIR influences the self-renewal of AML stem cells by modulating epigenetic factors or reduces the sensitivity of AML cells to chemotherapy drugs, thereby lowering patient survival rates through multiple pathways (Rajagopal et al., 2020; Gao et al., 2018; Zhou et al., 2021). Here, HOTAIR is linked to acute myeloid leukemia.