There is also the selective exclusion of significant variants such as rs429358 and rs7412 or other variants in the APOE locus in the AD PGS studies given their dominant effect; this is typically justified to aid the discovery of novel variants outside this well-known locus; however, this can also bias the results of RA, potentially underrepresenting the crucial roles of these variants in AD. This evidence concerns the gene APOE and Alzheimer disease.