demonstrated that ferroptosis occurs in neurons at the early stage of cerebral ischemia and that HMGB1 can upregulate the expression of hepcidin through TLR4/C-X-C chemokine receptor type 4 (CXCR4) to promote ferroptosis and aggravate cerebral ischemia. The gene discussed is HMGB1; the disease is Cerebral ischemia.