STAT1 and autoimmune disease: In another autoimmune disease, Sjogren’s syndrome, high expression of IFN-γ could decrease the expression of solute carrier family 3 member 2 (SLC3A2, a subunit of xCT), glutathione, and GPX4 in salivary gland epithelial cells and then trigger ferroptosis through activation of the JAK/STAT1 pathway, which can be inhibited by JAK1/2 or STAT1 antagonists (178).