Additionally, the metabolite of cholesterol, 7α, 25-dihydroxycholesterol (7α, 25-OHC), is dramatically elevated in the plasma of SLE patients and binds to the G protein-coupled receptor (GPCR) Epstein–Barr virus-induced gene 2 (EBI2) in macrophages to alleviate the IFN and ISG response for protecting against SLE progress (118). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.