Several pro-inflammatory cytokines including TNF-α, IL-1α, IL-1β, IL-6, IL-8, MCP-1, IFN-γ that are responsible for the cytokine storm in COVID-19 (31, 32) may induce COVID-19-associated coagulopathy (CAC) via expression of TF on ECs, monocytes, macrophages and T cells (33–40). This evidence concerns the gene CXCL8 and COVID-19.