ECs treated with human sera from COVID-19 hospitalized patients (n=118) demonstrated anti-cardiolipin IgG/IgM and anti-phosphatidlyserine/prothrombin (anti-PS/PT) IgG/IgM-driven elevation of surface adhesion markers E-selectin, VCAM-1, and ICAM-1 (100–102). This evidence concerns the gene CD40LG and COVID-19.