However, there were 3 patients who discontinued all protocol therapy due to either a Grade 4 alanine aminotransferase (ALT) increase and a Grade 4 aspartate aminotransferase (AST) increase after 3 cycles of treatment on DL0 (1 pt), a Grade 4 ALT increase and Grade 3 AST increase after 2 cycles of treatment on DL1 (1 pt), or a Grade 3 hyponatremia, hypoxia, and maculopapular rash (which resolved with topical steroids) after 1 cycle of treatment on DL1 (1 patient). Here, GPT is linked to Hyponatremia.