Along these lines, Ramakrishnan et al., identified THCs in the ascitic fluid of patients with epithelial ovarian carcinoma by utilising a combination of CA125/CD45 and EpCAM/CD45 biomarkers (72), while Aguirre et al., used the CD36/CD14/PANK (pan-cytokeratin) signature to identify hybrids in both tumour tissue and peripheral blood of lung cancer patients (47). This evidence concerns the gene PANK1 and lung cancer.