Focusing on macrophage populations related to the process of tumorigenesis, it has been described that tumour-associated macrophages (TAMs) are recruited into the tumour microenvironment (TME) by cancer cells, inflammatory cytokines and growth factors, such as chemotactic chemokine (CCL2) and CSF-1/M-CSF, among other molecules (79, 80). The gene discussed is CSF1; the disease is neoplasm.