Only 7 patients (18.4%) experienced grade 3-4 TRAEs, including increased aspartate aminotransferase (3 patients, 7.9%), elevated alanine aminotransferase (2 patients, 5.3%), elevated bilirubin (2 patients, 5.3%), neutropenia (2 patients, 5.3%), anemia (1 patient, 2.6%), and thrombocytopenia (1 patient, 2.6%). The gene discussed is GPT; the disease is neutropenia.