Additionally, by combining the tumor-selective ROS production and leaked Zn2+-induced glutathione reductase (GR) inactivation, ZnDHT NM enabled remarkable redox dyshomeostasis within tumor cells, triggering cellular oxidative damage and activating an impressive apoptosis-ferroptosis synergistic effect to kill tumor cells without noticeable cytotoxicity to normal cells. This evidence concerns the gene GSR and neoplasm.