NLRP3 and eosinophilia-myalgia syndrome: The NLRP3 inflammasome pathway is implicated in the pathophysiology of EMs.5 Additionally, TMP was demonstrated to have anti-inflammatory effects that alleviate acute lung injury and reduce pyroptosis through the NLRP3/caspase-1 pathway.13 Hence, we speculated that TMP may inhibit pyroptosis in EMs.