NFE2L2 and eosinophilia-myalgia syndrome: Accordingly, this study analyzed the mechanism of TMP in oxidative stress and NLRP3-dependent pyroptosis during the progression of EMs, and our experimental results elucidated that TMP hampered oxidative stress and NLRP3-regulated pyroptosis and might activate the Nrf2/HO-1 pathway in rats with EMs.