Results showed that in CIMP PM cells, activated (Z-score ≥ 2) UR were mainly associated with the BP involved in shutting down of the immune response (i.e., negative response to type I interferon, negative regulation of T-helper (Th)−17 type immune response, and negative regulation of T cell cytokine production), in cancer cell invasion and drug resistance (i.e., Hippo signaling pathway), and in tumor progression (i.e., TORC1 signaling) (Fig. 4 A; Additional file 5). Here, CRTC1 is linked to neoplasm.