MAPT and Alzheimer disease: The association between tau SUVR and neurodegeneration was significant using both AD cortical thickness (standardized β=-0.24, p = 0.005) and early-phase perfusion (standardized β=-0.44, p < 0.001), but not the hippocampal volume; however, a significant sex-by-tau interaction effect was found only on early-phase perfusion indicating a stronger association in men in the whole sample (standardized β=-0.56, p = 0.044) (Fig. 2D) and in amyloid-positive subsample (standardized β=-1.54, p = 0.012).