Besides, these genes were enriched to 8 Gene Ontology (GO) biological processes and 17 GO molecular functions, including regeneration, pyridine-containing compound biosynthetic and metabolic process, water-soluble vitamin metabolic process, protein kinase inhibitor activity, and etc. In addition, these genes were enriched to 13 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including p53 signaling pathway, JAK-STAT signaling pathway, type II diabetes mellitus, and etc. (Fig. 1E&F, Supplement Table 3&4). The gene discussed is TP53; the disease is type 2 diabetes mellitus.