The expression of 4 biomarkers between the T2DM and HC samples were compared, and the results showed that MIOX, MYCN, CD82 were lowly expressed, and CDKN1A was highly expressed in T2DM samples, among them, the expression of CDKN1A and MYCN showed significantly different in both of GSE76895 and GSE41762 (Fig. 9A, B). The gene discussed is CD82; the disease is type 2 diabetes mellitus.