INS and Insulin resistance: N6-methyladenosine (m6A) modification is a highly prevalent RNA modification that has been shown to play a critical role in numerous biological processes, including post-transcriptional regulation, RNA splicing, RNA stability, and RNA translation [4–6].Changes in m6A modification levels have been shown to regulate insulin signaling pathways, glucose metabolism, insulin secretion, and the function of islet beta cells, thereby influencing insulin resistance and the development of T2DM [7–9].