Furthermore, FadA, a virulence protein of F. nucleatum, binds to E-cadherin to trigger a decrease in β-catenin phosphorylation and subsequent activation of β-catenin-regulated transcription, leading to increased oncogenic MYC expression, which upregulates the expression of immunosuppressive programmed cell death ligand 1 (PD-L1) and CD47 in cancer cells [72]. The gene discussed is CD274; the disease is cancer.