In addition, Mandelboim, O. et al. found that F. nucleatum could bind and activate inhibitory receptors such as T cell immune receptor with immunoglobulin and ITIIM domain (TIGIT) and Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) to inhibit natural killer (NK) cell cytotoxicity and T cell activity, thus enhancing colorectal cancer progression [64, 65]. The gene discussed is CEACAM1; the disease is colorectal cancer.