Furthermore, the surface adhesin Fap2 of F. nucleatum can induce the secretion of pro-inflammatory cytokines IL-8 and C-X-C motif chemokine ligand 1 (CXCL1) and NOD-like receptor family pyrin domain containing 3 (NLRP3) activation to promote tumor migration and invasion [131]. This evidence concerns the gene CXCL8 and neoplasm.