In this study, we have identified a group of APMB-specific analytes (IL-10, CXCL1, IL-12p40, IL-13, CCL22, CCL4, IL-17A, and TGFα) that correlates with several clinical phenotypes associated with more severe SAB (diabetes, dialysis dependence, metastatic infection, and cardiac vegetation). The gene discussed is CCL4; the disease is diabetes mellitus.