In contrast, circCORO1C is upregulated in AD patients and associated with clinical traits and AD-associated genes including APP. Acting as a sponge for miR-105, circCORO1C reduces miR-105 bioavailability, leading to increased APP expression, which may exacerbate amyloid plaque formation and synaptic dysfunction (Fig. 3F). Here, APP is linked to Alzheimer disease.