However, studies of fibroblasts derived from patients with Li-Fraumeni syndrome (LFS), an inherited disorder where germ-line mutations in TP53 are of a similar nature to those reported by Redman-Rivera et al. do show LOH associated with the chromosome arm containing the wildtype allele of TP53 as part of observed increased genomic instability [43, 44]. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.