TP53 and cancer: Notably, five of the six genes responsible for lipid peroxide production (ALOX12, ALOX12B, ALOX15, ALOX15B and ALOX3E) are located on chromosome 17p, four of them (ALOX12, ALOX12B, ALOX15B and ALOX3E) within 1Mbp of TP53. Reduced expression of any of the five ALOX genes on 17p has been shown to increase resistance to ferroptosis in various cell models [145–149], and selective downregulation of ALOX15 has been linked with chemo-resistance in gastric and other cancers [150, 151].