The rapid cell proliferation associated with del17p can also potentially be explained by haploinsufficiency of MNT which antagonises Myc [79]; downregulation of MNT protein is reported to facilitate MYC-driven transformation in Burkitt’s lymphoma [80] and is associated with adverse prognosis in renal clear cell carcinoma [81]. The gene discussed is MYC; the disease is clear cell renal carcinoma.