Finally, increased cell proliferation would be supported by changes to metabolic processes; del17p in CLL cells is associated with increased basal metabolism [85] resulting in increased lactate production and respiration, metabolic alterations observed to closely resemble the switch to aerobic glycolysis that promotes proliferation and survival of CLL cells exposed to B cell receptor (BCR) crosslinking. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.