LOH of the proteasome 20S Subunit Beta 6 (PSMB6), located at 17p13.2, also results in haploinsufficiency, and in myeloma the STAT3 inhibitor, stattic, is reported to inhibit PSMB6 protein function to restore sensitivity to the proteasome inhibitor, bortezomib [161]. This evidence concerns the gene PSMB6 and plasma cell myeloma.