Indeed, western blot analysis confirmed upregulation of pro-apoptotic activator BCL2-like 11 (BCL2L11/BIM), and downregulation of pro-apoptotic sensitizer phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1/NOXA) in both HA lymphoma cell lines (compared to the respective cell lines cultured under normoxia) (Fig. 3B). This evidence concerns the gene BCL2L11 and lymphoma.