BCR and acute lymphoblastic leukemia: To understand the consequences of CDK6-mediated gene expression, we made use of our transcriptomics data obtained in BCR::ABL1 transduced CDK6 wildtype (Cdk6+/+), kinase inactive Cdk6K43M (Cdk6KM/KM), and knockout (Cdk6−/−) primary bone marrow cells (Fig. 1A) [12, 34, 35], resembling an early stage of BCR::ABL1+ ALL.