Cancer stem cells (CSCs) constitute a minor fraction of the tumor population, characterized by their capacity for self-renewal and differentiation.138,139 A plethora of compelling evidence substantiates that CSCs play a pivotal role in driving tumor initiation, conferring resistance to treatment, facilitating recurrence, and promoting metastasis.140,141 Although CSCs represent a functional cellular state, it has been demonstrated that their identification can be facilitated by utilizing specific cell markers such as CD133, CD44, EPCAM, and ALDH1, among others.142. Here, CD44 is linked to neoplasm.