This facilitates the nuclear translocation of YAP1, subsequently triggering the transcription of ALDH1A1. Pharmacological inhibition of downstream signal transduction mediated by KK-LC-1 significantly impairs TNBC tumor growth.144 EMSY is also a newly discovered biomarker of TNBC CSCs, It competitively binds to the Jmjc domain, which is critical for KDM5B enzyme activity, thereby reshaping methionine metabolism in CSCs. Here, ALDH1A1 is linked to neoplasm.