Exercise on specific body part, such as upper limb exercises, can also help alleviate lymph node edema in breast cancer patients.530 A subtyping study demonstrated that HR+/HER2− breast cancer was more responsive to exercise than other subtypes,531 while another basic study has pointed out that exercise did not impact the proliferation of breast tumors but has changed their gene expression.532 Interestingly, it was reported that the benefit of exercise on breast cancer patients was partially mediated by changes in insulin levels.533. This evidence concerns the gene INS and breast neoplasm.