This hypothesis is supported by recent research showing significant changes in biomarkers of tubular injury, urine neutrophil gelatinase-associated lipocalin (NGAL), after radical nephrectomy [34], and evidence linking AKI after nephrectomy in adults to increased risk of CKD, morbidity, mortality, and prolonged hospitalization [29, 31, 39]. This evidence concerns the gene LCN2 and acute kidney injury.