The analysis revealed significant differences in the tumor microenvironment between MRD‐positive and MRD‐negative patients, particularly in macrophages (W = 15 848; p < 0.01), resting CD4 memory T cells (W = 13 249; p < 0.01), and Tfh cells (W = 10 935; p < 0.01) (Figure 3A). This evidence concerns the gene CD4 and neoplasm.