Reversal agents aimed at restoring haemostasis, thus logically appear as promising treatments.6, 8 The gold standard of VKA reversal is currently a combination of prothrombin complex concentrate (PCC) and vitamin K.9Multiple studies have shown excellent and quick reversal, yet these findings have not been consistently translated into improved clinical outcomes in intracerebral haemorrhage.10 11 PCC is also used for DOAC reversal and in particular in activated factor 10 (FXa) inhibitor-associated bleeds.8 The gene discussed is F10; the disease is intracerebral hemorrhage.