Hence, this study aims to evaluate the IgA, IgM, and IgG immune responses to key myelin-related proteins, including MBP, PLP, MOG-35–55, MOG-31–55, citrullinated-MOG (CIT-MOG), myelin-associated glycoprotein (MAG)-37–60, and GLIAL-CAM-370–399, in RRMS patients. Here, CD40LG is linked to relapsing-remitting multiple sclerosis.