More than 10 years ago Basu and co-workers analyzed the expression of LEDGF/75 in 21 different tumor types and demonstrated elevated LEDGF/p75 mRNA levels in solid colorectal cancer tissues obtained from random samples.12 Briefly, Basu and co-workers used the human ‘TissueScan Cancer Survey Panel 96–I’ QPCR array (CSRT-101, OriGene Technologies Inc., Rockville, MD, USA) for in-house analysis of LEDGF/p75 mRNA expression in 96 tissues covering 8 major human cancer with datasets obtained from the Oncomine database (Compendia Biosciences; Ann Arbor, MI, USA; https://www.oncomine.org). Here, PSIP1 is linked to cancer.