PSIP1 and neoplasm: The variability of GAPDH expression has been noted in previous cell culture studies where increased GAPDH expression was observed with LEDGF/p75 overexpression.11 LEDGF/p75 is known to be critical for genomic integrity, promoting DNA repair and acting as a transcriptional co-activator by expressing oncogenes like Hsp27 under stress conditions.11,17 The dual function of LEDGF/p75 as both an oncoprotein and a tumor suppressor through the DNA repair mechanism is a false reciprocity.