CD4 and Increased total eosinophil count: Indeed, depletion of CD4+ cells just before final allergen challenge (Figure S8A) or genetic ablation of IL-17A/F (Figure 3F) compromised CXCL5 accumulation (Figures 3G and S8B) and allergic neutrophilia (Figures 3H, S8C, and S8D), but not eosinophilia (Figure 3I), in the airways of LH mice despite their extensive inhalation experience.