GZMB and neoplasm: Two pairs were evaluable by IHC; one patient achieved PR and showed an increase of 36% (166.31-226.61 cells/mm2) and 344% (22.11-98.2 cells/mm2) in CD8+ and granzyme B+ cells, respectively, in the central tumor region; the other patient was non-responsive and showed an increase of 107% (123.13-255.1 cells/mm2) in CD8+ and 725% (10.97-90.5 cells/mm2) in granzyme B+ cells (Supplementary Figure S4A, available at https://doi.org/10.1016/j.esmoop.2025.104291).