TNIK and ovarian carcinoma: For example, TNIK has been shown to regulate TGF-β signaling in fibroblasts to promote proliferation and differentiation into myofibroblasts while enhancing cell survival by activating c-Jun N-terminus kinase (JNK) [29], and TNIK inhibition suppresses tumor cell growth and invasion in colon and ovarian cancer through Wnt signaling [30, 31].