ACOD1 and neoplasm: In line with earlier findings in Irg1-deficient macrophages (Chen et al., 2022b; Mills et al., 2018), siIrg1 electro-transfection led to upregulation of inflammatory cytokine and chemokine genes, such as Il1b, Il6, and Cxcl9, in mBMDMs following exposure to tumor conditioned medium (TCM) from B16-F10 melanoma cells (Fig. S2A).