IL6 and acute respiratory distress syndrome: Since nanoparticlescan be easily phagocytosed by macrophages, they effectively modulatemacrophage-mediated inflammatory responses.40 Research has highlighted the potential of nanomedicine in targetedmacrophage therapy for ALI, particularly through regulating macrophagepolarization.20 Our study elucidated thepotential mechanism by which FTY720-NOB-PLGA NPs attenuate ALI, specificallyby suppressing macrophage recruitment and reducing IL-6 and ROS secretion,thereby decreasing neutrophil accumulation.