NFASC and acute respiratory distress syndrome: These results indicate that FTY720 has a protectiveeffect against LPS-induced ALI, likely via the inhibition of NF-κBactivation and the regulation of inflammatory pathways to amelioratealveolar capillary barrier dysfunction.11 Another study investigated the anti-inflammatory effects of NOBin LPS-stimulated A549 cells and LPS-induced ALI in mice.