NFKB1 and acute respiratory distress syndrome: The trigger pathway of ALI, including nuclear factorκ-light-chain-enhancer of activated B cells (NF-κB) andp38 mitogen-activated protein kinase, was also efficiently inhibited.Furthermore, the inhalation treatment provided a good safety profile,without detrimental effects on biochemical markers and lung function.We provided the feasibility of administering inhalation of NPs noninvasivelywith continuous monitoring of lung function.