RNF114 has been found to play a pivotal role in cancer, shaping metastasis, therapeutic response, and tumor development.[35, 36] In this study, we found that circFADS1 can attach to RNF114 and act as a scaffold for RNF114 and GSK3β, promoting their interaction, and exhibiting oncogenic characteristics. The gene discussed is GSK3B; the disease is neoplasm.