GSK3B and cancer: Also, abnormal Wnt/β‐catenin activation drives cancer initiation and progression.[31] For the liver, research has shown that the homeostasis of the liver and the occurrence of HCC are closely associated with the Wnt pathway.[32] Under normal circumstances, β‐catenin is sequestered in the cytoplasm, forming a complex with APC, AXIN1, and GSK3β, which phosphorylates its N‐terminus.