Beyond tumor cell-intrinsic markers, we found that expression of PDCD1 (PD-1) by non-tumor cells was highly associated with multiple TIPC subtypes, hinting at regulation of immune cell spatial distributions by CD274 (PD-L1)/ PDCD1 (PD-1) immune checkpoint signaling between different immune cell populations. The gene discussed is PDCD1; the disease is neoplasm.