This complex binds to the promoter of CUL4A/4B and induces its expression, activating the CUL4A/4B‐associated E3 ligase‐CRL4, which leads to the ubiquitination and degradation of ST7 by the CRL4 E3 ligase, promoting the occurrence of colorectal cancer [97]. This evidence concerns the gene IL17RB and colorectal cancer.