Utilising mass spectrometry and immunoprecipitation, Lu et al.'s identified in colorectal cancer that c‐Myc, along with its partner MAX (Myc‐associated factor X), histone acetyltransferase p300, and CARM1, forms a CARM1‐p300‐c‐Myc‐Max (CPCM) transcription complex. This evidence concerns the gene EP300 and colorectal cancer.