EFNA1 and colon adenocarcinoma: Subsequent transcriptome analyses of tumors with an activated EFNA1-SE (detected ratio >1%) revealed that EFNA1 upregulation was predominantly observed in CC and colon adenocarcinoma (COAD) tumors (Supplemental Figure 4G and Supplemental Figure 5G), highlighting a tumor-specific SE-driven activation of EFNA1 in certain cancer types.