The percentage of cells with high TOM20 expression (defined as cytoplasm score greater than 3+ in ImageScope’s Cytoplasmic v2 algorithm, see Methods for details), indicating high mitochondrial content, was decreased in Msh2KO tumor tissue (4.78%) compared with control endometrium (14.29%) (P < 0.01) (Figure 2B). Here, TOMM20 is linked to neoplasm.