My research unveiled an innovative prognostic framework grounded in the analysis of 19 distinct genes related to m6A modifications and ferroptosis processes (including AKR1C1, IFNA10, IFNA21, CDO1, BRD2, ATF2, ATG16L1, HDDC3, DAZAP1, BCAT2, FTH1, HNRNPA2B1, BRD4, ATG3, AKT1S1, DHODH, CYGB, HSF1, and FADS2), identified within the TCGA-NB project and further validated through two independent patient cohorts from the GEO database. This evidence concerns the gene AKT1S1 and neuroblastoma.