A total of 4 of the 12 genes (NEB, PLEC, XIRP2, TTN) and 9 other genes (ARID1B, CACNA1A, CELSR1, KMT2C, LRP2, AHNAK, COL7A1, LAMA5, RYR1) are also related to congenital heart disease. This evidence concerns the gene RYR1 and congenital heart disease.