We studied three distinct and extensively studied cell states for comparison: hESCs (H9), representing an undifferentiated state, differentiated cells (CD19 + primary B-cells, monocytes, neutrophils, T-cells, and cardiomyocytes), and B-cells from chronic lymphocytic leukemia (B-CLL) patients, as a representation of a cancerous leukemic cell state [31, 39]. This evidence concerns the gene CD19 and B-cell chronic lymphocytic leukemia.