Considering that GCF is one of the sources of IL-1β in salivary, individuals in the gingivitis group (mean missing teeth n = 0.18 ± 0.72) had fewer missing teeth than those in the periodontitis group (mean missing teeth n = 1.89 ± 1.74), resulting in more GCF containing IL-1β flowing into the salivary, potentially leading to increased salivary concentrations of IL-1β in the gingivitis group. The gene discussed is IL1B; the disease is periodontitis.