Additionally, X‐linked VEXAS (V: vacuoles; E: E1 ubiquitin conjugating enzyme encoded UBA1; X: X chromosome; A: autoinflammatory; S: somatic mutations) syndrome represents one of the most frequent autoinflammatory syndromes that typically presents during the second half of life, contributing to the understanding of rare diseases such as relapsing polychondritis.166. The gene discussed is UBA1; the disease is autoinflammatory syndrome.