We found that circCCNB1 promoted the processing and generation of miR‐15b‐5p and miR‐7‐1‐3p through competitive binding to NF90, thereby inhibiting the expression of calumenin (CALU), kinesin family member 1B (KIF1B), RNA polymerase III subunit G (POLR3G), ultimately decreasing the VM of NPC cells. Here, CALU is linked to nasopharyngeal carcinoma.