ACE and hypertensive disorder: For example, α-aminoketones, exhibiting a wide spectrumofregulatory properties, serve as the basis for antidepressant drugs(Bupropion),13 appetite suppressants (Amfepramone),14 ACE inhibitors for hypertension treatment (Keto-ACE),15,16 or antiplatelet agents (Prasugrel).17 Similarly, the β-aminoketone skeleton can be found in Proroxane(nonselective α-adrenergic blocker),18,19 Tolperisone (vasodilation),20 Oxyfedrine(coronary artery disease),21 or Sitagliptin(antidiabetic).22