We confirm that genetically predicted lower SBP is causally associated with reduced risks of all outcomes, in concordance with evidence from previous studies.24,25 We found protective effects of genetically proxied AGTi, ERA, sGCs, and PDE5i for CAD, MI, and ischaemic stroke, and the protective effect of sGCs for CKD. The gene discussed is ASIP; the disease is chronic kidney disease.