We detected a significant association of PDE5A gene expression level in the aorta with the risk of CAD (per 1-SD increase in gene expression level, bSMR = 0.171, PSMR = 9.12 × 10−06, PHEIDI = 0.338), and a nominal association with the risk of MI and T2D (Supplementary material online, Table S13, Figure 3, Fig. S3). Here, PDE5A is linked to type 2 diabetes mellitus.