Genetically proxied AGTi was significantly associated with a reduced risk of CAD (OR per 10 mmHg decrease in SBP, 0.647, 95% CI, 0.515–0.814, P = 0.0002) and ischaemic stroke [0.487 (0.333–0.712), P = 0.0002]. The gene discussed is ASIP; the disease is ischemic stroke.