Our in vivo results indicate that the inhibition of HIFs by FM19G11, as well as its downstream effectors of the pathway, VEGF/VEGFR1 autocrine loop (31), and EGF/EGFR autocrine loop markedly reduced tumor growth as well as the expansion of the EpCAM+/ABCG2+ cells. The gene discussed is VEGFA; the disease is neoplasm.