CAF-CD70 and CAF-SLPI were predominantly enriched in para-cancerous tissues of plaque stage (MF1_b2), whereas CAF-WNT2 and CAF-COL4A4 were mainly enriched in para-cancerous tissues of tumor stage (MF1_c2) (Supplementary Figure 5C). The gene discussed is COL4A4; the disease is neoplasm.