Compared with the reactive T cells, the expression of tumor-associated genes upregulated in malignant T-cell subsets, including Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2), Thymocyte Selection Associated High Mobility Group Box (TOX), Gametocyte Specific Factor 1 (GTSF1), CD40 Ligand (CD40LG) (Figure 3E; Supplementary Figure 3). This evidence concerns the gene CD40LG and neoplasm.