PLAUR and migraine disorder: While increasing evidence implicates inflammation in the meninges and cortical inflammation within the CNS as key pathophysiologic mechanisms in migraine,4,5 a definitive characterization of these inflammatory processes remains pending.6 In this context, soluble urokinase plasminogen activator receptor (suPAR) has emerged as a promising blood-based biomarker for understanding the low-grade chronic inflammation that might underlie migraine.7