BAX and neuroblastoma: In research conducted on human neuroblastoma cell lines (SH-SY5Y), it was discovered that the TSG enhances cell survival and reduces the likelihood of programmed cell death, or apoptosis, by increasing the levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and the survival-promoting protein Bcl-2, while simultaneously decreasing the levels of the pro-apoptotic protein Bax (Kang et al., 2024).