Exo70 is a key component of an octameric protein complex that facilitates the association of the Arp2/3 complex with the Wiskott-Aldrich syndrome protein family verproline-homologous protein-2 (WAVE2), thereby influencing F-actin polymerization and playing a crucial role in the formation of lamellar pseudopods and the maintenance of cell migration orientation persistence (Liu et al., 2012; Zhu et al., 2019; Kullmann et al., 2020), While Exo70 has been implicated in tumor cell migration, its role in stem cell therapy has not been fully explored. The gene discussed is ACTR2; the disease is neoplasm.