Notably, hyperlipidemia stimulation significantly decreased the mRNA expression levels of TLR-4 (Figure 2D) and TLR-2 (Figure 2I) by 69.1% (P < 0.001) and 68.1% (P < 0.05), and 52.1% (P < 0.01) and 38.6% (P < 0.05), respectively, in PCSK9liver(−/−) and PCSK9liver(+/−) mice as compared to that of PCSK9liver(+/+) mice. Here, TLR4 is linked to hyperlipidemia.