FLT3 and leukemia: Moreover, FLIN-4 substantially inhibits FLT3 autophosphorylation and the phosphorylation of downstream key target proteins in MV4-11 cells, suggesting its ability to interrupt critical nodes within the FLT3 signaling axis, thereby disrupting the proliferative and survival signaling of leukemia cells and potentially overcoming resistance arising from the aberrant activation of downstream pathways.